Investigation about the Relationship between Dyslipidemia and Urinary Calculi as Well as Their Components
ZHENG Lei,CHEN Xiang,YIN Bo-wei
Abstract:
Objective To explore the relationship between each indice of serum lipid and the formation as well as composition of urinary calculi in patients with urinary calculi. Methods 430 cases of urinary calculi patients (urolithiasis group) and 500 cases of healthy persons (control group) in our hospital were included in this study with their clinical data retrospectively analyzed. After admission, peripheral blood of patients in the two groups and calculi of urolithiasis group were collected, and total cholesterol (TC), blood triglyceride (TG), plasma low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were detected. We collected the stones of urolithiasis group and determined their composition. Various lipid indexes of urolithiasis group and control group were analyzed and compared using Statistical methods, and multivariate Logistic regression was used to analyze the independent risk factors of urolithiasis caused by the above mentioned dyslipidemia. We compared the lipids of patients with different stone compositions，and analyzed which stone composition cause by dyslipidemia as an independent risk factor. Results There were statistically significant differences in total cholesterol (TC), plasma low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) levels between the two groups (P <0.05). However, there were no statistically significant differences in blood triglyceride (TG) levels between the two groups (P >0.05). Multiple logistic regression analysis showed that hyperlipidemia and family history entered the variable model, with OR values and 95% Cl of 1.321(1.145, 1.467) and 2.234 (1.768, 2.814). In the stone group, 430 cases were analyzed,including 163 cases (37.9%) with dyslipidemia, 82 cases (50.3%) with uric acid stones; 267 cases (62.1%) with normal blood lipid and 82 cases (30.7%) with uric acid stones. The proportion of uric acid stones between the two groups was statistically significant(P<0.05 ). Correlation analysis showed that dyslipidemia was closely related to hyperuricemia (r= 0.226, r = -0.597, P < 0.001). Multivariate adjusted logistic regression analysis showed that total cholesterol was an independent risk factor for urinary stone formation (P = 0.001). Logistic regression analysis showed that triglyceride was an independent risk factor for urinary calculus formation (P = 0.001). Conclusion Dyslipidemia, especially high TC, high LDL-C and low HDL-C, is closely related to the occurrence of urinary calculi. Patients with dyslipidemia are more likely to have uric acid stones than those with normal blood lipids.
