Clinical Observation of Kudiezi Combined with Low Molecular Weight Heparin on Preventing Deep Venous Thrombosis of Lower Extremities after Pelvic and Acetabular Fractures in Elderly Patients
JIAO Jia-xun,ZHU Xiao-li
Department of Pharmacy, Hengshui People' s Hospital, Hengshui, Hebei 053000, China
Abstract:
Objective To investigate the clinical effect and mechanism of Kudiezi injection combined with low molecular weight heparin on preventing deep venous thrombosis of lower extremities after pelvic and acetabular fractures in elderly patients. Methods From January 2018 to January 2019, 100 elderly patients of pelvic and acetabular fractures in our hospital were divided into the observation group (n =50) and the control group (n =50) randomly. Besides conventional treatments, the control group was given low molecular weight heparin, while the observation group was given Kudiezi injection and low molecular weight heparin. Then, the incidence of DVT, the degree of limb swelling and pain, hemodynamic indexes, level of inflammatory factors and adverse reactions were observed and compared. Results 30 days after operation, the incidence of DVT in the observation group was 6%, which was statistically lower than that of 20% in the control group (P <0.05). One week after operation, hemodynamic indexes and inflammatory factors in the observation group were respectively statistically lower than those in the control group (P <0.05). The degree of limb swelling and pain was statistically lower than that of the control group (P <0.05). The incidence of adverse reactions in the observation group was 6%, which was statistically the same with that of 4% in the control group (P >0.05). Conclusion Treatment of Kudiezi injection combined with low molecular weight heparin can effectively prevent the incidence of lower extremities DVT on elderly patients after pelvic and acetabular fractures. It can significantly improve hemodynamic indexes and alleviate inflammatoryreaction with minor adverse reactions.
