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中药辅助微创椎间孔镜技术治疗腰椎间盘突出症的疗效及对血浆 hs-CRP、CPK、IL-6水平的影响
于亚东,刘孟军
重庆市云阳县人民医院脊柱与创伤骨科重庆 404500
摘要:
目的:研究中药辅助腰椎间盘突出患者行微创椎间孔镜技术( PTED)治疗的临床疗效及血浆超敏 C-反应蛋白(hs-CRP)、肌酸磷酸激酶( CPK)、白细胞介素 -6(IL-6)水平的变化。方法:选取我院 2014年 2月—2017年 6月收治的腰椎间盘突出患者 72例,分为两组,常规组 36例行椎板开窗手术治疗,研究组 36例行微创椎间孔镜手术治疗,为两组患者在术后 3天开始服用独活寄生汤,分别于术前、术后 3、6、12、24及 48 h检测血浆 hs-CRP、CPK、IL-6水平情况,并比较两组患者术中出血量、住院时间及伤口大小等情况。结果:研究组术中出血量(6.7±3.4)mL显著低于常规组(82.6±16.5) mL,差异有统计学意义(t=28.136,P<0.05);研究组住院时间( 2.4±0.6)d显著短于常规组(5.7±1.4)d;差异有统计学意义(P<0.05);研究组伤口大小( 0.5±0.1)cm显著小于常规组(5.0±1.3)cm,差异有统计学意义(P<0.05);常规组血清 IL-6与 CPK均在术后 3 h出现明显升高,而研究组均在术后 6 h升高,但研究组血清 IL-6与 CPK水平均显著低于常规组,差异均有统计学意义(P均 <0.05);常规组血清 hs-CRP在术后 6 h出现明显升高,而研究组在术后 12 h出现明显升高,两组均在术后 24 h达峰值,但研究组血清 hs-CRP水平显著低于常规组,差异有统计学意义( P<0.05)。结论:中药独活寄生汤辅助 PTED治疗腰椎间盘突出对患者身体损伤小,且能达到与椎板开窗手术治疗的相同疗效。
关键词:  腰椎间盘突出症  独活寄生汤  椎间孔镜技术  疗效
DOI:10.3969/j.issn.1007-6948.2020.04.017
投稿时间:2019-10-12
基金项目:
Effect of Traditional Chinese Medicine Assisted Minimally Invasive Percutaneous Endoscopic Technique in Treatment of Lum Bar Disc Herniatien and Its Effect on Plasma Factor Hs-CRP, CPK and IL-6
YU Ya-dong,LIU Meng-jun
Department of Spine and Trauma Orthopaedics, Yunyang County Peoples’Hospital, Chongqing 404500, China
Abstract:
Objective To explore the clinical effect of Traditional Chinese medicine assisted minimally invasive percutaneous endoscopic technique (PTED) in the treatment of lum bar disc herniatien and the changes of high sensitivity C-reaction protein (hs-CRP), creatine phosphate kinase (CPK) and interleukin-6 (IL-6) of plasma factor. Methods  72 cases of lum bar disc herniatienin in our hospital during February 2014 to June 2017 were randomly divided into 2 groups. 36 cases of conventional group were received vertebral lamina fenestration surgery and 36 cases in the study group were received minimally invasive percutaneous endoscopic surgery. The patients in both groups began to take Duhuo Jisheng decoction 3 days after operation. The data of hs-CRP, CPK, IL-6 of two groups were recorded preoperative and postoperative 3,6,12,24 and 48h respectively and they were compared with intraoperative blood loss, length of stay and wound size. Results The intraoperative blood loss (6.7±3.4)mL in the study group was signi?cantly lower than that in the conventional group (82.6±16.5) mL, which the difference was statistically signi?cant (t=28.136, P<0.05). The length of stay of the study group (2.4±0.6)d was signi?cantly shorter than that of the conventional group (5.7±1.4)d, which the difference was statistically signi?cant (P<0.05). The wound size (0.5±0.1)cm in the study group was signi?cantly smaller than that of the conventional group (5±1.3)cm (P<0.05). 3 hours after surgery, the serum level of IL-6 and CPK in the conventional group were signi?cantly increased, while the study group were elevated after 6 hours (P<0.05). The level of serum hs-CRP in the conventional group was higher than that of the study group and it signi?cantly increased 6 hours after surgery, while the study group increased after 12 hours, and both of them were peaked after 24 hours (P<0.05). Conclusion Traditional Chinese Medicine Duhuo Jisheng decoction which assisted PTED treatment can achieve the same effect as vertebral lamina fenestration surgery with low damages.
Key words:  Lum bar disc herniatien  Duhuo Jisheng decoction  percutaneous transforaminal endo-scopic discectomy  effect

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