Effect of Wentong Method on the Curative Effect of Intestinal Node-Yang Deficiency and Cold Coagulation and the Effects of TNF-α and Interleukin- 6
YANG Ying-ying,WANG Meng,ZHU Peng-fei
Abstract:
Objective To observe the effect of Wentong method on the efficacy of intestinal node-yang deficiency and cold coagulation syndrome and the effects of TNF-αandinterleukin-6. Methods Seventyfivepatients with intestinal node-yang deficiency and cold coagulation syndrome were selected and divided into control group, treatment group A and treatment group B, which 25 cases in each group. Control group:conventional treatment; treatment group A: Wentongsan external applicationShenqueacupoint + conventional treatment; treatment group B: Wentongsan external applicationShenqueacupoint + traditional Chinese medicine enema + conventional treatment. Compare the clinical indicators and changes of TNF-α and interleukin-6 levels in the above threegroups. Results Abdominal pain( groupA: 2.80±0.70, group B: 2.16±0.74), abdominal distension ( groupA: 2.52±0.58, group B: 2.08±0.64), first exhausttime ( groupA: 3.96±0.84, groupB :3 . 20 ± 0 . 57 ),first defecation time ( groupA:5 . 20± 0 . 70 , group B: 4 . 40 ± 0 . 73 ), recovery time of bowel sounds ( groupA: 2 . 12 ± 0 . 60 ,group B: 1.76±0.66). The treatment group were improved than those in the control group(P <0.05) :abdominal pain (3.32±0.94), abdominal distension(2.96±0.84), first exhaust time (4.92±0.90), firstdefecationtime(6.04±0.97), recovery time of bowel sounds (2.64±0.63). The TCM syndrome ( groupA: 80%, group B: 92%) and clinical ef?cacy (groupA : 80%, group B: 92%). The treatment group were improved than those in the control group(P<0.05): TCM syndrome (64%) and clinicalsymptomsef?cacy (60%). The TNF-α [( groupA: (41.62±1.55) pg/mL, group B: (31.51±1.40) pg/mL], interleukin -6 [( groupA: (45.93±3.18) pg/mL, group B: (31.54±2.49) ng/mL] in the treatment group was lower than those in the control: TNF-α [(54.41±1.35) pg/mL], interleukin-6[(71.89±2.94) ng/mL]. The clinical parameters, laboratory parameters, TCM syndrome and clinical effect in group B was higher than those in group A(P<0.05). Conclusion Wentong method is effective in treating intestinal node-yang de?ciency and cold coagulation.It canimprove clinical symptoms, promote the recovery of gastrointestinal function and reduce the levels of TNF-α and interleukin-6.
