Effect of Huo Xue Tong Jiang Fang on Clinical Effect and Gastric Emptying of Reflux Esophagitis of Blood Stasis and Collaterals Blocking Type
KANG Li-li,TANG Yan-ping,YANG Li
Department of Gastroenterology,Tianjin Nankai Hospital, Tianjin300100,China
Abstract:
Objective To observe the clinical efficacy of Huo Xue Tong Jiang Fang in treating Reflux esophagitis (RE) with blood stasis and obstruction of collaterals and its effect on gastric emptying, and to explore the mechanism of action of Huo Xue Tong Jiang Fang from the perspective of gastric motility. Methods 89 RE patients with blood stasis and obstruction of collaterals from January 2017 to December 2017 were randomly divided into three groups. Group A (western medicine treatment group): rabeprazole + ITO ratio. Group B (traditional Chinese medicine treatment group): Huo Xue Tong Jiang Fang. Group C (integrated Chinese and Western medicine group): Western medicine + Huo Xue Tong Jiang Fang. The course of treatment in the three groups was 8 weeks. Before and after treatment, digestive tract symptom score (RDQ questionnaire), TCM syndrome score, gastroscopic grading (LA) and gastric emptying (solid half emptying time) were compared and analyzed. Results After treatment, digestive tract symptom score and TCM syndrome score of the three groups were significantly improved compared with those before treatment, and the difference was statistically significant(P<0.05). The improvements of digestive tract symptom score after treatment were as follows: Group C was better than group A and group B (P < 0.05). There was no significant difference between group A and group B(P> 0.05). After treatment, the improvement degree of TCM syndrome score in group C was better than that in group B and group B was better than A. There was statistical difference between the two groups(P<0.05 ). After LA grading treatment under gastroscope, the three groups improved in different degrees compared with those before treatment. The improvement of group A and group C was better than that of group B (P < 0.05), but there was no significant difference between the other two groups (P > 0.05). The indexes of gastric emptying in three groups were significantly improved after treatment (P < 0.05). The improvement degree of group C was better than that of group A and group B (P < 0.05), but there was no significant difference between group A and group B (P > 0.05). Conclusion Huo Xue Tong Jiang Fang can improve the clinical symptoms and gastroscopic mucosal manifestations of RE patients with blood stasis and obstruction of collaterals.Regulating gastric emptying and gastric motility maybe one of the mechanisms of treating RE.
