《中国中西医结合外科杂志》杂志社

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基于中医“因虚致瘀”论治结合微创手术对腰椎间盘突出症疗效及血TNF-α、IL-1β 水平的影响
吴亚东,齐晓艳,韦庆申,鲁玉州,王金国,汉吉健
山东省日照市中医医院骨伤三科日照276800;山东省日照市人民医院药剂科日照276800

摘要:

目的:根据中医“因虚致瘀理论”辨证结合经皮内窥镜下腰椎间盘髓核摘除术(PELD)治疗血瘀气滞型腰椎间盘突出症的疗效及对外周血肿瘤坏死因子-α(TNF-α)和白细胞介素-1β(IL-1β)水平的影响。方法:选取2016 年1 月—2018 年4 月日照市中医医院收治的血瘀气滞型腰椎间盘突出症患者90 例，随机分为2 组，治疗组45 例采用益气和血方药配合PELD 治疗，对照组45 例采用PELD 治疗，观测并比较2 组术前和术后2 周、2 个月的Oswestry 功能障碍指数(ODI)、疼痛评分(VAS)、血清TNF-α 和IL-1β 水平及住院天数。结果:两组均有40 例患者获得随访，2 组术后2 周、2 个月的ODI 评分、VAS 评分、TNF-α 水平与治疗前比较均显著降低(P <0.01)，2 组术后2 周、2 个月IL-1β 与治疗前比较，差异有统计学意义(P <0.05)。治疗组术后2 周ODI 评分、TNF-α 水平优于同期对照组(P <0.05)，治疗组术后2 个月ODI评分、TNF-α 水平优于同期对照组(P <0.05)，治疗组术后2 个月的VAS 评分、IL-1β 与对照组比较显著降低(P <0.01)。结论:血瘀气滞型腰椎间盘突出症行PELD 术后结合中医“因虚致瘀”理论辨证论治，可降低术后外周血TNF-α 和IL-1β水平，减轻术后疼痛，提高术后早期疗效，促进患者快速康复。

关键词: 因虚致瘀理论腰椎间盘突出症肿瘤坏死因子-α 白细胞介素-1β

DOI：10.3969/j.issn.1007-6948.2020.03.026

投稿时间：2019-09-17

基金项目:

Clinical Efficacy of Stasis Caused by Deficiency Combined With Minimally Invasive Surgery for Lumbar Disc Herniation and Effects of TNF-α and IL-1β in Peripheral Blood

WU Ya-dong,QI Xiao-yan,WEIQing-shen

Abstract:

Objective To observe the efficacy of “Stasis Caused by Deficiency Theory” combined with percutaneous endoscopic lumbar intervertebral discectomy (PELD) in the treatment of Qi stagnation and blood stasis of lumbar disc herniation and the effect of levels of Peripheral blood tumor necrosis factor-α(TNF-α) and interleukin-1β (IL-1β), further to explore the TCM theoretical mechanism and scientific connotation, and to provide new ideas for clinical diagnosis and treatment. Methods Statistical analysis of patients from January 2016 to April 2018, 90 patients with Qi stagnation and blood stasis of lumbar disc herniation are randomly divided into 2 groups. 45 patients in the treatment group were treated with qi benefiting and blood harmonizing herbal

Key words: Theory of stasis caused by deficiency lumbar disc herniation tumor necrosis factor-α interleukin-1β

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