Effect of Huoxue Tongjiang Formula on Electrogastrogram in Patients with Reflux Esophagitis of Static Blood Blocking Collaterals Syndrome
GONG Yan-xia,TANG Yan-ping,LI Shu-hong
Department of Gastroenterology, Tianjin Nankai Hospital, Tianjin 300100, China
Abstract:
Objective To observe the effect of Huoxue Tongjiang Formula on Electrogastrogram (EGG) in reflux esophagitis (RE) with syndrome of static blood blocking collaterals and to explore the mechanism of action of Huoxue Tongjiang Formula by electrophysiology. Methods 60 RE patients with static blood blocking collaterals syndrome were selected and randomly divided into two groups. Western medicine group (30 cases):Omeprazole + Domperidone + Hydrotalcite; Chinese and Western medicine group (30 cases): Omeprazole +Huoxue Tongjiang Formula. The symptomatic scores, gastroscopic manifestations and Electrogastrogram were compared before and after treatment for 4 and 8 weeks. Results Western medicine group: Western medicine symptomatology score: before treatment (20.59±4.25), 4 weeks after treatment (16.21±3.02), 8 weeks after treatment (9.32±2.08), the difference was statistically significant; Chinese medicine symptomatology score:before treatment (43.28±8.09), 4 weeks after treatment (35.06±5.03), 8 weeks after treatment (18.23±4.09),the difference was statistically significant; gastroscope grading: before treatment: 8 cases of A, 16 cases of B, 6 cases of C; 8 weeks after treatment: 14 cases returned to normal, 10 cases of grade A, 5 cases of grade B and 1 case of grade C. Chinese and Western medicine group: Western medicine symptomatology score: before treatment (19.38±3.05), 4 weeks after treatment (15.23±2.12), 8 weeks after treatment (7.23±3.12),the difference was statistically significant; Chinese medicine symptomatology score: before treatment(45.41±7.12), 4 weeks after treatment (35.34±4.11), 8 weeks after treatment (15.12±5.21), the difference was statistically signi?cant. Gastroscope grading: before treatment: there were 7 cases of A, 15 cases of B, 8 cases of C, 8 cases of C; 8 weeks after treatment: 16 cases returned to normal, 9 cases in grade A, 5 cases in grade B and 0 in grade C. Compared with the western medicine group, the improvement of symptoms and endoscopy in the Chinese and Western medicine group had more advantages. The main manifestations of electrogastrogram were the decline of main frequency, normalization trend of slow wave percentage, and the decrease of the percentage of gastric tachycardia, slow gastric motility and rhythm disorder. Conclusion Huoxue Tongjiang Formula can alleviate the clinical symptoms and emotions, improve the performance of the mucosal manifestations in gastroscope for RE patients with static blood blocking collaterals syndrome, which had the function of mucosal protection and dynamic regulation. Its mechanism may be effected through regulating gastroesophageal myoelectric activity and electrical rhythm disorder.
