Application of Dexmedetomidine and Epidural Block in Laparoscopic Radical Resection of ColorectalCancer in Elderly Patients under General Anesthesia
GAO Yu-ting,ZHANG Shu-bo,GAO Xiao-zeng
Department of Anesthesia, North China University of Science and Technology Affiliated Hospital, Tangshan063000, China
Abstract:
Objective To compare the effects of dexmedetomidin combined general anesthesia and epidural combined general anesthesia on the stress response and postoperative recovery of elderly patients with laparoscopic radical resection of colorectal cancer. Methods A total of 60 elderly patients with colorectal cancer undergoing laparoscopic surgery were selected, with age 65 or older, ASA grade I or II. It was randomly divided into two groups, with 30 cases in each group. Group D was induced by 10 min intravenous infusion of dexmedetomidine 0.8 μg/kg before anesthesia induction. After intubation, right metodetomidine was injected to 0.5 μg/(kg · h) to the preoperative 30 min, and the patients in group E were fixed on T4. The dosage of narcotic drugs was recorded during the operation (T0), immediately after endotracheal intubation (T1), 5 min (T2) after pneumoperitoneum (T2), 30 min (T3) after pneumoperitoneum (T3), and immediately after extubation (T4) to determine the concentration of E, NE, Cor and GLU. The VAS score of the patients 1 h, 6 h,12 h, 24 h and 48 h after surgery, postoperative exhaust time, eating time, hospital stay and related complications were recorded. Results At T2 and T3, the heart rate of group D was significantly slower than that of group E (P <0.05). At T2 and T3, the heart rate of group D was significantly slower than that of T0 (P <0.05).The concentration of E, NE and Cor in group D at time points T1 and T2 was lower than that in group E(P <0.05). There was no significant difference in
