Effects of Enhanced Recovery after Surgery on Postoperative Systemic Inflammatory Stress State and Rehabilitation Quality of Patients Undergoing Laparoscopic Cholecystectomy
YANG Wei-gang
Department of General Surgery, Changxing Country People’s Hospital, the Second Af.liated Hospital of Zhejiang Medical University, Changxing 313100, China
Abstract:
Objective To investigate the effect of enhanced recovery after surgery (ERAS) on systemic inflammatory stress and rehabilitation quality after laparoscopic cholecystectomy. Methods Totally 110 patients with gallbladder polyps admitted to our hospital during January 2017 to January 2019 were randomly divided into control group and ERAS group, with 55 cases in each group. Patients in control group were treated with routine perioperative intervention, while those in ERAS group were treated with perioperative ERAS intervention. The degree of inflammatory reaction, oxidative stress reaction and rehabilitation were compared between two groups. Results After 24 h of operation, the serum levels of in.ammatory factors (IL-6, IL-8 and IL-35) in ERAS group were lower than those in control group; the levels of oxygen free radicals (ROS) and malondialdehyde (MDA) in ERAS group were lower than those in control group, and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were higher than those in control group (P<0.05). After 48 h of operation, there was no signi.cant difference in levels of in.ammatory factors and oxidative stress indexes between two groups (P>0.05). Postoperative exhaust time and hospitalization time in ERAS group were shorter than those in control group, incision pain, nausea and vomiting incidence in ERAS group were lower than those in control group (P<0.05). There was no significant difference in the incidence of pulmonary infection and lower extremity venous thrombosis between two groups (P>0.05). No abdominal hemorrhage occurred in either group. Conclusion ERAS can effectively alleviate the short-term inflammation and stress reaction after laparoscopic cholecystectomy, accelerate the recovery of the body and reduce the occurrence of complications to a certain extent.
