Curative Effect Observation on Laparoscopic Surgery Combined with Omeprazole Triple Therapy in Treatment of Gastroduodenal Ulcer Perforation
DING Zhi-hai,WANG Wei,XIONG Rui
Department of Anorectal Surgery, Tianjin Haibin People' s Hospital, Tianjin 300280, China
Abstract:
Objective To investigate the ef.cacy of laparoscopic surgery combined with Omeprazole triple therapy in the treatment of gastroduodenal ulcer perforation. Methods The clinical data of 146 patients with perforated gastroduodenal ulcer were retrospectively analyzed. The patients were divided into routine group and observation group by randomized digital table method was, with 73 patients in each group. The patients in the routine group underwent routine symptomatic treatment after laparoscopic repair surgery. The patients in the observation group were treated with conventional Omeprazole triple therapy after surgery. The levels of in.ammatory factors (C-reactive protein, interleukin-6, and tumor necrosis factor-α) at the time of admission and 7 days after surgery were detected, and the time required for HP to become negative, hospital stay, eating time and drainage tube placement, as well as the clinical effect and complication rate were investigated. Results There were no signi.cant differences in serum in.ammatory factors between the two groups when admitted to hospital (P>0.05). The serum in.ammatory factors levels in the observation group were lower than those in the routine group at 7 days after surgery (P<0.05). The time required for Hp to be negative, hospitalization time, feeding time and drainage tube placement time in the routine group were longer than those in the observation group, with statistical difference (P<0.05); The short-term ef.cacy of the observation group was 97.26% (71/73), which was better than that of the conventional group [93.15% (68/73)]; the number of dislocations between the routine group and observation group were 2 and 3.In the conventional group, the incidence of complications such as intestinal obstruction and re-perforation was 11.27% (8/71), which was higher than that of the observation group [5.71% (4/70)](P<0.05). Conclusion For patients with clinical gastroduodenal perforation, laparoscopic surgery combined with Omeprazole triple therapy, the overall clinical effect is more obvious and and the incidence of complications decreased, meanwhile the safety can be improved.
