Effect of Transcutaneous Acupoint Electrical Stimulation on Conscious Sedation of Midazolam
GUO Yan-hui,ZHAO Chong-fa.
Department of Anesthesiology, Tianjin Haihe Hospital, Tianjin 300350, China
Abstract:
Objective To investigate the effect of transcutaneous acupoint electrical stimulation (TAES) on sedation of midazolam. Methods Totally 80 patients undergoing lower limb surgery under elective spinal anesthesia in our hospital were randomly divided into two groups (n=40): TAES group and control group. In the TAES group, TAES was given after spinal anesthesia. The frequency of stimulation parameters was 2/100 Hz and the wave width was 0.2–0.6 ms. The stimulation current was adjusted to the maximum intensity that the patients could tolerate. Bilateral Hegu and Neiguan acupoints were selected as acupoints, and midazolam was injected by target-controlled infusion 20 min later. The patients in the control group applied electrodes at corresponding acupoints and connected stimulator without electric stimulation. The patients were scored by OAA/S and the target-controlled infusion concentration of midazolam was adjusted according to BIS, Ce, BIS, midazolam dosage, SpO2 , MAP, HR, .umazenil use and adverse reactions were observed and recorded when OAA/S score was 3 min for the .rst time. Results The target concentration of midazolam in the TEAS group (60.3±8.0) ng/mL was lower than that in the control group (66.8±8.5) ng/mL (P<0.05), and the dose of midazolam in the TAES group (4.9±0.6) mg was less than that in the control group (5.3±0.5) mg (P<0.05). There were 12 cases in the TEAS group and 28 cases in the control group, with signi.cant difference (P<0.05); there were no signi.cant differences in BIS, SpO2, MAP and HR between the two groups (P>0.05). Conclusion TAES can enhance the sedative effect of midazolam and reduce the dosage of midazolam.
