Clinical Study on Fuyuan Huoxue Decoction Combined with Visceral Acupoint Massage in Treatment of Osteoporotic Vertebral Compression Fracture
LIU Bo,SU Xiao-qiang,WANG Xiang-yang,HU Xing-lv,GUAN Hai-ying,JIANG Chun-feng,WANG Jing-bo
Department of Spinal Surgery, Xi' an Traditional Chinese Medicine Hospital, Xi' an (710000), China
Abstract:
Objective To evaluate the clinical study of Fuyuan Huoxue Decoction (FHD) combined with visceral acupoint massage in treatment of osteoporotic vertebral compression fracture (OVCF), furthermore, to discuss the therapeutic mechanism of the disease and the effect of serum CRP and TNF-α on the condition. Methods The patients with OVCF ( 114 cases) that accorded with the inclusion criteria were selected randomly and divided into treatment group and control group (n=57). For various reasons in the process of treatment, 2 cases quit in treatment group, 5 cases quit in control group, and 107 cases ?nally completed the test (55 cases in treatment group, 52 cases in control group, loss rate of 6.14%). The patients in treatment group were given FHD combined with visceral acupoint massage, the patients in control group were given general abdominalmassage combined with Xianling Gubao Tablets, 2weeks for a course and 2 courses of treatment. The VAS score, anterior vertebral height and kyphosis angle, serum CRP, TNF-α levels and the averagetime of pain disappearance and abdominal distension disappearance were compared between the two groups before treatment, after 2 courses of treatment and half a year of follow-up. Results After 2 courses, VAS score after six months of follow-up was compared with that before treatment, and the difference was statistically signi?cant, P=0.000<0.01; the VAS score in treatment group after two courses of treatment was [(3.04±1.02)vs ( 4 . 26± 1 . 03), t = – 2 . 531], and that after six months follow-up was [( 0 . 92± 0.25) vs (2.55 ± 0 . 37), t =–2.862], which was lower than the control group (P<0.05). The changes of anterior vertebral height and kyphosis angle in treatment and control groups after 2 courses of treatment and 6 months of follow-up were signi?cantly different from those before treatment (P = 0 . 000< 0 . 01). There was no significant difference in the changes of anterior vertebral height and kyphosis angle between the two groups after 2 courses (P>0.05). After 6 months of follow-up, the changes of anterior vertebral height in treatment group [(1.57±0.13) mm vs (1.13±0.12) mm, t=–2.993] and posterior convex angle changes [(4.35±1.02)? vs (6.63±1.28)?，t=–3.586] were higher than control group; the average time of pain disappearance in manipulation group[(7.33±2.42) d vs (11.28±5.69) d，t =–3.884], and the average time of abdominal distension disappearance [(2.67±1.73) d vs (5.31±2.02) d， t=–3.142] were lower than that of the control group (P < 0.05). The levels of CRP and TNF-α in the treatment and control groups after 2 courses of treatment and 6 months of follow-up were signi?cantly different from those before treatment (P <0.05).Conclusion FHD combined with visceral acupoint massage to treat OVCF have higher safety, satisfactory clinical ef?cacy, high compliance with patients, and can reduce the levels of serum CRP and TNF-α in?ammatory factors.
