Effect of Buyang Huanwu Decoction on Hypercoagulable State after Total Knee Arthroplasty
LI Qin-zong,WEI Wan-li,ZHENG Kun-lun,XIN Jin-dang,GU Fu-shun
Department of Orthopaedics, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin (300150), China
Abstract:
Objective To observe the effect of Buyang Huanwu Decoction (BHD) on postoperative hypercoagulability in patients after total knee arthroplasty (TKA). Methods Eighty-four patients after TKA were randomly divided into treatment group (n=42) and control group (n=42). In the control group, the patients were treated with subcutaneous intramuscular injection of low molecular weight heparin calcium (4100 U, QD, once daily), and the patients in treatment group were injected subcutaneously with low molecular weight heparin calcium combined with oral BHD (QD, 100 mL/time, twice daily). Results Plasma fibrinogen (Fib) and D-dimmer (DD) in the treatment and control groups were signi?cantly higher than those after 14 d of surgery, with statistically signi?cant difference (P<0.05), and there was statistically signi?cant difference (P<0.05) after 14 d of surgery. The levels of plasminogen (PLG) of two groups 14 d after surgery were lower than those preoperative, with a signi?cant difference, and there was a statistically signi?cant difference between the two groups after 14 d (P<0.05). Prothrombin time (PT) and activated partial thromboplastin time (APTT) were compared with those before surgery. The time was signi?cantly shortened, but there was no statistically signi?cant difference (P>0.05). The time was signi?cantly longer than that before surgery on day 7 and 14 after surgery. There was no signi?cant difference in statistics (P>0.05), there was no statistically signi?cant difference between the two groups (P>0.05).The changes of tPA and PAI- 1 before and after treatment in the two groups were compared before and 1 d after surgery. There was no signi?cant difference (P > 0 . 05 ). There were significant differences in the treatment group between tPA and PAI-1 at 7 and 14 d after treatment, respectively (P<0.05). There were signi?cant differences between the two groups in tPA and PAI- 1 at 14 d postoperatively (P <0.05). Conclusion BHD can effectively improve the percoagulable state of patients after TKA, relieve clinical symptoms and improve quality of life.
