The Efficacy and Safety of Multi-point Injection of Gemcitabine by Bladder Submucosa in PKRBt for Treating Superficial Bladder Cancer
LIU Yang,XIA Hou-ping
Department of Urology, Tongzhou Chinese Medicine Hospital, Nantong(226300),China
Abstract:
Objective To analyze the ef?cacy and safety of multi-point injection of gemcitabine by bladder submucosa in PKRBt for treating superficial bladder cancer. Methods Selected 48 cases of patients with super?cial bladder cancer, who were treated by PKRBt, and all were con?rmed as NMIBC by pathology after operation. The selected patients were randomly divided into group A and group B, with 24 cases in each group, Group A was treated with multipoint GEM injection during PKRBt operation, and group B was treated with immediate GEM infusion after PKRBt operation. Toxicity and side effects were compared between the two groups, and tumor recurrence and quality of life were compared during follow-up. Results The survival rates of 1, 1.5 and 2 years without tumor recurrence were 91.7%, 83.3%, 79.2% in group A, while that of group B was 87.5%, 58.3% and 50.0% (log-rank test χ2= 4.216, P= 0.040<0.05), in addition, the recurrence survival rate of 1, 1.5 and 2 years without FISH was 79.2%, 66.7% and 66.7% in group A, while that of group B was 58.3%, 37.5% and 37.5% (log-rank test χ2= 4.110, P= 0.043<0.05); There was no significant difference (P>0.05) in the mean score of bladder irritation between the two groups, and all the patients were relieved after drinking water or symptomatic treatment; There were no signi?cant differences in the incidence of toxic reactions between the two groups (all P>0.05), and the symptoms of multiple renal function injuries and gastrointestinal reactions were relieved after symptomatic treatment, and one of the patients with bone marrow suppression in group B was treated with granulocyte stimulating factor (g-csf),and the blood picture returned to normal; During the 1 -year follow-up after surgery, the scores of the four dimensions of body, mind, society and material life of the patients in group A were higher than those in group B, and the differences were statistically signi?cant (all P <0.05). Conclusion GEM injection through the submucosa of the bladder during PKRBt operation of NMIBC has good curative effect, good tolerance and high safety, reduce recurrence rate, and improved the postoperative quality of life of patients, which is worthy of clinical application.
