Influence of Bugan Jianyao Decoction on IL-1 Expression and Neurological Function Score in Rat Lumbar Disc Herniation
TAN Xu-yi,ZHAO Di-min,QIU Xiang-zhong,CHOU Jie,Jiang Sheng-chang,ZHANG Xin-cheng,TANG Hao
Hunan University of TCM, Changsha (410208), China
Abstract:
Objective To observe the in?uence of Bugan Jianyao Decoction (BJD) on IL-1and neurological function score in rat lumbar disc herniation. Methods Totally 100 rats were randomly divided into normal control group, sham-operated group, model control group, BJD group and Celecoxib group, each group with 20 rats.After rat lumbar disc herniation model was prepared successfully, BJD group were gived the BJD intragastric administration, while Celecoxib group was given Celecoxib, normal control group, Sham-operated group, model control group were intragastrically administrated with the same dose of normal saline. IL- 1 expression and neurological function score were detected at the moment of the experimental intervention, the intervention of the 1, 2, 3 weeks. Results At the moment of the intervention,compared with the model control group,there was no statistically signi?cant that IL-1 expression and neurological function score in lumbar intervertebral disc local tissue of BJDgroup and Celecoxib group (P>0.05).After the intervention of the 1, 2, 3 weeks by BJD, IL-1 expression of BJDgroup were 19.29±0.61, 14.54±0.23, 14.01±0.21 respectively, were decreased than that of model control group (P<0.05),meanwhile, neurological function score of BJDgroup were 2.60±0.55, 2.40±0.5,2.20±0.84 respectively, were decreased than that of model control group (P < 0 . 05),after the intervention of the 1 , 2 , 3 weeks. Meanwhile, IL- 1 expression and neurological function score of BJDgroup were decreased than that at the moment of the intervention when after the intervention of the 1 , 2 , 3 weeks (P <0.05). Conclusions Bugan Jianyao Decoction has the effect of reducing IL-1 expression, improving neurological function score, it may be a mechanism for the treatment of lumbar disc herniation.
