Morphological Study on Prevention of Qingre Jiedu Herbs and Liangxue Huoxue Herbs for Postoperative Abdominal Adhesion in Rats
BAI Jing-rui,WU Xian-zhong,LIU ong-bin,LIU Dong-hua,CUI Li-hua,GAO Qiao-ying,ZONG Chun-hui,ZHANG Yi
Tianjin Nankai Hospital, Tianjin (300100), China
Abstract:
Objective To observe the prevention of Qingre Jiedu Herbs and Liangxue Huoxue Herbs on postoperative abdominal adhesion in rats and explore the mechanism. Methods The healthy Wistar rats (120 cases) were randomly divided into 6 groups and then made into postoperative abdominal adhesion model by duodenum clamped. The protective measures or medicines were given respectively for 7 d, and the survival rate was recorded. Adhesions were evaluated on day 14 post-surgical, specimens were collected for histological staining and grading. Results There was no difference in survival rate of 4 treatment groups and model group (P>0.05). The scores of adhesion range and strength, the ?brosis and neovascularization and the content of type I and III collagen of Qingre Jiedu group were lower than those in other treatment groups (P<0.05). The in?ammation had no statistical difference (P >0.05) Conclusion Qingre Jiedu Herbs and Liangxue Huoxue Herbs can both decrease the postoperative abdominal adhesion formation, and the effect of Qingre Jiedu Herbs was better. The reason may be that these herbs can suppress inflammatory, promote the recovery of bowel movement, reduce the in?ammatory exudation and ?brin substrate transformation after the operation.
