Analysis on Predictive Value of NK, Th17 and Treg Cells on Recurrence of Colorectal Carcinoma after Laparoscopic Resection
ZHANG Fan,DI Tai-ling,HAN Ke-song
Department of General Surgery, China National Petroleum Corporation Central Hospital, Langfang (065000), China
Abstract:
Objective To investigate the influences of the levels of NK cells, Th17 cells and Treg cells on clinical outcomes of patients with colorectal carcinoma after laparoscopic resection, and to analyze their predictive value for postoperative recurrence. Methods The clinical data were collected from 120 patients with colorectal carcinoma who underwent laparoscopic resection bfrom January, 2016 to January, 2017. The levels of NK cells, Th17 cells and Treg cells in peripheral blood were obtained and detected on day 1 postoperatively. Two independent t-test samples were used to analyze the difference between patients with recurrence and those without recurrence. Logistic regression model was used to determine the correlation between the indicators and recurrence. Finally, ROC curve was used to analyze its value in predicting recurrence of colorectal cancer after operation. Results We found that levels of NK cells and Th17 cells in recrudesce patients were lower than those in non-recrudesce patients (P < 0 . 05 ), but the level of Treg cells in recrudesce patients were higher than that in non-recrudesce patients (P<0.05). Logistic regression analysis found that NK cells and Th17 cells were protective factors for recurrence, while Treg cells were independent risk factors. ROC curve analysis showed that the levels of NK cells, Th17 cells and Treg cells had certain predictive value for predicting postoperative recurrence. Conclusion Levels of NK cells, Th 17 cells and Treg cells are associated with recurrence and independent prognostic influencing factors for postoperative patients with colorectal carcinoma, and its has acertain value in predicting postoperative recurrence of patients.
