Application of Allogeneic Venous Vascular Replacement in Extended Pancreatoduodenectomy for T3 Stage Pancreatic Head Cancer
ZHANG Hui, ZHAO Xin, ZHANG Xing-mao, et al.
Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing(100020), China.
Abstract:
Objective To explore the safety and application value of allogeneic vascular replacement in the treatment of stage T3 pancreatic head cancer combined with venous resection and reconstruction. Methods The clinical data of 98 patients with stage T3 pancreatic head cancer with portal and/or splenic vein invasion who underwent extended pancreaticoduodenectomy combined with venous resection and reconstruction were retrospectively analyzed. Among them, 49 patients underwent extended pancreaticoduodenectomy combined with portal and/or splenic vein resection and allogeneic vascular reconstruction according to age and sex, as group A. Forty-nine patients, who matched with group A, received extended pancreaticoduodenectomy with other reconstruction methods as control group (group B). Results The operation time of group A was no longer than that of group B, and the amount of bleeding during operation in group A was larger than that in group B, but there was no statistical difference. The resection rate of portal vein and/or splenic vein in group A was higher than that in group B, and the incidence of complications was similar between the two groups. The overall survival rate of group A was slightly higher than that of group B, and the disease-free survival rate increased after 1 year and 2 years of operation. Conclusion Expanded pancreaticoduodenectomy with allogeneic vascular replacement and reconstruction for stage T3 pancreatic head cancer does not increase the operation time, intraoperative bleeding and postoperative complications, and can increase the resection rate of R0 and prolong the survival time of patients. It is feasible, safe and effective.
