The Correlation Factor Analysis of Axillary Non-sentinel Lymph Node Metastasis in Sentinel Lymph Node Positive Breast Cancer Patients: a Study of 102 Patients.
ZHENG Ke-si, ZHENG Xiang, ZENG Yong,et al.
Department of Oncology, Wenzhou People’s Hospital,the Third Clinical College of Wenzhou Medical University，Wenzhou, Zhejiang (325000), China
Abstract:
Objective A retrospective study was conducted on the clinicopathologic data of patients with early breast cancer of which sentinel lymph node positive undergoing the axillary lymph node dissection (ALND).And to analyze the related risk factors of axillary non-sentinel lymph node (NSLN) metastasis.And in order to establish a nomogram model suitable for local patients. Methods Clinical and pathological data of the early breast cancer patients with sentinel lymph node positive and further received the axillary lymph node dissection was collected from January 2009 to December 2016 in Wenzhou People’s Hospital .Univariate analysis and multivariate Logistic regression analysis were applied to analyse the relationship between these clinicopathological factors and NSLN metastasis. Results In this study, 102 patients with SLN positive breast cancer were further received ALND, among which 36 cases of NSLN turned out to be metastatic positive, and the NSLN transfer rate was 35.3% (36/102).According to the univariate analysis results:. Histologic classification (χ2=8.8214，P=0.0030), SLN transfer rate≥0.5 (χ2=5.2377，P=0.0221), SLN metastatic foci > 2mm(χ2=4.3290，P=0.0370) were risk factors for NSLN transfer.Multivariate Logistic regression analysis showed that:SLN transfer rate≥0.5(OR=1.63, 95%CI: 1.29-2.10, P=0.001), and SLN metastatic foci > 2mm(OR=1.34, 95%CI: 1.02-2.12, P=0.032)were independent predictors of NSLN transfer. Conclusion SLN transfer rate≥0.5, the maximum diameter of SLN metastases > 2mm may be risk factors of NSLN metastasis in breast cancer,which can be further used to construct a model that suitable for local patients.
