Efficacy and Safety Analysis of Botulinum Toxin Injection Combined with Intravesical Instillation of Heparin in Treatment of Interstitial Cystitis
XIE Liang, CAO Di, MA Huang-bin
Department of Urology, Cangzhou People' s Hospital, Cangzhou (061000), China
Abstract:
Objective To evaluate the clinical effects of botulinum toxin injection (BTI) combined with heparin + sodium bicarbonate + lidocaine bladder perfusion for the treatment of interstitial cystitis. Methods Twenty patients with interstitial cystitis were randomly divided into two groups. BTI + heparin + lidocaine + sodium bicarbonate and intravesical sodium hyaluronate were used for the therapy, respectively. BTI (200 U) was injected, and 2% lidocaine (8 mL) + heparin (37 500 million U) + 5% sodium bicarbonate (5 mL) were used for bladder perfusion after 3 d. This therapy was repeated once a week and last for a month. In sodium hyaluronate group, intravesical instillation of sodium hyaluronate was used once a week and lasted for one month. Results Then all patients were followed up. The symptom score, problem score, daily urination frequency and maximum bladder volume in sodium hyaluronate group were not significantly improved compared with those before treatment (P>0.05); the above indicators in the combined group were significantly improved compared with those before treatment (P<0.05). Conclusion BTI combined with heparin + sodium bicarbonate + lidocaine + intravesical therapy treat for interstitial cystitis was more effective than sodium hyaluronate.
