Effect of Simo Decoction on Gastrointestinal Function after Operation of Esophageal Cancer
YAO Guang-huai, DENG Bin, SHI Qing-tong
Department of Gastroenterology, the Affiliated Hospital of Yangzhou University, Yangzhou (22500), China
Abstract:
Objective To investigate the effect of early postoperative nasal jejunal tube feeding with Simo Decoction on the recovery of gastrointestinal function after esophageal cancer operation Methods Eighty patients with esophageal cancer surgery were divided into study group and control group (n=40). The patients in study group were injected with 20 mL of Simo Decoction through the nasal jejunal feeding tube every 8 h after 6 h of operation, and 10 mL warm saline was used to flush the tube before and after injection. The patients in control group were injected with 40 mL warm saline every 8 h after operation. The recovery time of bowel sounds, first deflation and defecation time, and incidence of bloating, nausea, and vomiting were compared between the two groups. The levels of serum brain-gut peptide and gastrointestinal hormone were measured at 1 d before operation (T0), 1 d after operation (T1), 3 d after operation (T2) and 7 d after operation (T3). Results The average recovery time of bowel sounds in study group was (24.8±4.1) h, the first exhaust time was (32.6±3.9) h, and the first defecation time was (46.6±6.8) h, which were significantly shorter than those of the control group (29.1 ±4.2) h. (39.2 ±4.1) h, (58.2 ±7.1) h (P<0.05). The incidence of abdominal distension, nausea and vomiting in the study group was significantly lower than that in the control group (P<0.05). There were no significant differences between the two groups in the vasoactive intestinal peptide and serotonin values at T0, T1 and T2, and at T3 the study group was significantly lower than control group (P<0.05). There were no significant differences between the two groups in serum cerebral peptide and substance P at T0 and T1, and at T2 and T3 the indexes in study group were significantly increased compared with the control group (P<0.05). There was no significant difference in motilin and gastrin values between the two groups at T0, the indexes at T1 were higher than T0, and those at T2 and T3 were higher than T1, the value of study group was significantly higher than that of control group (P<0.05). There was no significant difference in GHRP and CRH values between the two groups at T0, the indexes at T1 decreased compared with T0, those at T2 increased compared with T1, and exceeded T0. The increase of GHRP at T2 and T3 in study group was significantly higher than that in control group, and the CRH in control group was significantly higher than that in study group (P<0.05). Conclusion Early nasal jejunal tube feeding with Simo Decoction can effectively promote the recovery of gastrointestinal function after esophageal cancer operation and reduce the occurrence of complications.
