Expression and Significance of FHIT and Ki67 in Bladder Urothelial Carcinoma
ZHANG Chun-ting, LIU Ran-lu, XU Yong
Department of Urology, Jinhua People's Hospital, Jinhua (321000), China
Abstract:
To observe the expression and correlation of FHIT and Ki67 protein in bladder urothelial carcinoma tissue. Methods The expression levels of FHIT and Ki67 protein in 66 cases of bladder cancer and 42 cases of normal bladder tissue were detected by immunohistochemical SP. Spearman correlation analysis was used to analyze the correlation between FHIT and Ki67 protein. Results The positive rate of FHIT protein was 92.85% in normal bladder tissue, and the positive rate in bladder urothelial carcinoma was 39.39%; Ki67 was the opposite, the expression rate in bladder urothelial carcinoma tissue was 90.91%, the expression rate in normal bladder tissue was 11.90%, while the abnormal expression of Ki67 and FHIT protein was related to the clinical stage and differentiation of bladder urothelial carcinoma. Spearman correlation analysis showed that FHIT was negatively correlated with Ki67 protein expression. Conclusion FHIT combined with Ki67 is detected helpful to evaluate the invasion ability and clinical prognosis of bladder urothelial carcinoma.
